Advances in treatments have dramatically improved long-term survival after childhood cancer to >85% in the US. However, childhood cancer survivors are at increased risk for experiencing severe and life- threatening health conditions as they age as a consequence of cancer therapy. Using a study of differences in treatment and mortality among childhood cancer survivors who developed subsequent breast cancer as an example, Dr. Lucie Turcotte will highlight the challenges in addressing survivors’ lifelong increased risk of multiple morbidity. Dr. Cindy Im will then discuss potential opportunities to facilitate personalized care, leveraging large epidemiological datasets, statistical/machine learning- based prediction modeling, and genetics to improve late effects clinical risk stratification.